W. P. Andrew Lee, MD

Adjunct Professor
W. P. Andrew Lee, MD - Headshot

Contact

443-287-2001

Johns Hopkins School of Medicine

601 N. Caroline Street, Suite 8152F

Baltimore, MD 21287, 

Biography

W. P. Andrew Lee, M.D. is the Milton T. Edgerton, MD, Professor and Chairman of Department of Plastic and Reconstructive Surgery at the Johns Hopkins University School of Medicine.  A hand surgeon and basic science researcher, he conducts investigation on tolerance strategy for vascularized composite allografts, such as hand or face transplants, to ameliorate the need for long-term systemic immunosuppression.

Dr. Lee is currently serving as the Chair of the American Board of Plastic Surgery and the Immediate Past President of the American Society for Surgery of the Hand. In 2008 he helped to found the American Society for Reconstructive Transplantation, for which he now serves as the President-Elect. He was elected the Chairman of Plastic Surgery Research Council in 2002 and President of the Robert H. Ivy Society of Plastic Surgeons in 2010-11. Dr. Lee has received more than 70 awards and honors, including the Kappa Delta Award from the American Academy of Orthopaedic Surgeons, and Sumner Koch Award and Sterling Bunnell Traveling Fellowship from the American Society for Surgery of the Hand.

Dr. Lee has mentored more than 70 pre-doctoral and post-doctoral researchers in over two decades, and has authored about 140 original publications in peer-reviewed journal and 40 textbook chapters on hand surgery and composite tissue transplant subjects.  He served on the editorial boards of Transplantation and Journal of Surgical Research, and has been an invited speaker or visiting professor in more than 40 institutions around the world.  The book co-edited by him, Transplantation of Composite Tissue Allografts, was published by Springer in 2008.

An honors graduate in physics from Harvard College, Dr. Lee received his medical degree from Johns Hopkins University School of Medicine, where he also completed his general surgery residency and microvascular research fellowship. He completed his plastic surgery fellowship at the Massachusetts General Hospital and his orthopedic hand fellowship at the Indiana Hand Center. In 1993 he joined the plastic surgery faculty at Massachusetts General Hospital, Harvard Medical School, and became director of the Plastic Surgery Research Laboratory and subsequently chief of hand service in Department of Surgery.  In 2002 Dr. Lee was recruited to the University of Pittsburgh, where he served as Division Chief of Plastic Surgery until 2010.

Dr. Lee established a multi-disciplinary program for hand transplantation at University of Pittsburgh Medical Center using an immunomodulatory protocol based partly upon findings in his laboratory.  He led the surgical team that performed the first bilateral hand transplant (2009) and the first above-elbow transplant (2010) in the U.S.  A salient feature of the protocol is single-agent immunosuppression (monotherapy) that minimizes the long-term risks of hand transplantation.

Publications

Lee WPA, Yaremchuk MJ, Pan YC, Randolph MA, Tan CM, Weiland AJ. Relative Antigenicity of Components of a Vascularized Limb Allograft. Plastic and Reconstructive Surgery, 87:401, 1991. | View Abstract »

Lee WPA, Pan YC, Kesmarky S, Randolph MA, Fiala TS, Amarante MTJ, Weiland AJ, Yaremchuk MJ. Experimental Orthotopic Transplantation of Vascularized Skeletal Allografts: Functional Assessment and Long-Term Survival. Plastic and Reconstructive Surgery, 95:336-349, 1995. | View Abstract »

Lee WPA, Mathes DW. Hand Transplantation: Pertinent Data and Future Outlook. J Hand Surg, 24A:906, 1999. | View Abstract »
 
Rubin JP, Cober SR, Butler PEM, Gazelle S, Ierino F, Randolph MA, Sachs DH, Lee WPA. Injection of Allogeneic Bone Marrow Cells Into Portal Vein of Swine In Utero. Journal Surg Research, 95:188, 2001. | View Abstract »

Lee WPA, Rubin JP, Cober S, Bourget J, Nielsen G, Randolph M, Ierino F, Sachs DH. Tolerance to Limb Tissue Allografts B/w Swine Matched in Major Histocompatibility Complex. Plastic Reconstr Surg, 107:1482, 2001. | View Abstract »
 
Mathes DW, Randolph M, Bourget J, Nielsen G, Ferrera V, Arn J, Sach DH, Lee WPA. Recipient Bone Marrow Engraftment in Donor after Longterm Tolerance to Comp Tissue Allograft. Transplantation, 73:1880,2002. | View Abstract »

Mathes DW, Randolph MA, Solari MG, Nazzal JA, Nielson GP, Arn JS, Sachs DH, Lee WPA. Split tolerance to a Composite Tissue Allograft in a Swine Model. Transplantation, 75:25-31, 2003. | View Abstract »

Hettiaratchy S, Melendy E, Randolph MA, Coburn RC, Neville DM, Sachs DH, Huang C, Lee WPA.  Tolerance to Composite Tissue Allografts Across a Major Barrier in Miniature Swine.  Transplantation 2004;77:514. | View Abstract »

Mathes DW, Solari MG, Randolph MA, Gazelle G, Huang C, Sachs D, Lee WPA.  Long-term Acceptance of Renal Allograft Following Prenatal Inoculation with Adult Bone Marrow.  Transplantation, 2005:80:1300. | View Abstract »

Solari MG, Washington KM, Sacks JM, Hautz T, Unadkat JV, Horibe E, Venkataramanan R, Larregina AT, Thomson AW, Lee WPA.  Daily Topical Tacrolimus Therapy Prevents Skin Rejection in a Rodent Hind Limb Allograft Model. Plast Reconstr Surg 2009;123:17S-25S. | View Abstract »

Washington K, Solari, Sacks, Horibe, Unadkat, Carvell, Simons, Lee WPA. Model for Functional Recovery Cortical Reintegration after Hemifacial Comp Tissue Allotransplant.  Plast Reconstr Surg 2009;123:26S. | View Abstract »

Kuo YR, Shih H, Goto S, Wang F, Lin C, Wu, Wang, Huang, Chen, Zheng, Lee WPA.  Mesenchymal Stem Cells Prolong Composite Tissue Allotransplant Survival in Swine Model.  Transplantation 2009;87:1769. | View Abstract »

Unadkat J, Schneeberger S, Horibe E, Goldbach C, Solari M, Washington K, Gorantla V, Afrooz P, Pulikkottil B, Cooper G, Thomson A, Lee WPA.  Composite Tissue Vasculopathy and Degeneration Following Multiple Episodes of Acute Rejection in Reconstructive Transplantation. Am J Transplant 2010;10:251. | View Abstract »

Shores JT, Imbriglia JE, Lee WPA.  The Current State of Hand Transplantation.  J Hand Surg 2011;36:1862. | View Abstract »

Schneeberger S, Gorantla VS, Brandacher G, Zeevi A, Demetris AJ, Lunz JG, Metes DM, Donnenberg AD, Shores JT, Dimartini AF, Kiss JE, Imbriglia JE, Azari K, Goitz RJ, Manders EK, Nguyen VT, Cooney DS, Wachtman GS, Keith J, Fletcher D, Macedo C, Planinsic R, Losee J, Shapiro R, Starzl TE, Lee WPA.  Upper Extremity Transplantation using a Cell-Based Protocol to Minimize Immunosuppression.  Ann Surg, 2012 Epub ahead of print.